Bispecific capturing molecule

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C436S514000, C436S810000, C436S547000, C435S328000, C435S007100, C435S007940, C435S970000

Reexamination Certificate

active

07989219

ABSTRACT:
A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the polypeptide chains has a domain having a hypervariable loop structure at a binding site binding to the target substance and an association portion for forming the association, and the polypeptide chains are associated via the association portions present in the polypeptide chains.

REFERENCES:
patent: 5529792 (1996-06-01), Risau et al.
patent: 5653675 (1997-08-01), Kanno et al.
patent: 5863789 (1999-01-01), Komatsu et al.
patent: 5910573 (1999-06-01), Pluckthun et al.
patent: 5969108 (1999-10-01), McCafferty et al.
patent: 6424418 (2002-07-01), Kawabata et al.
patent: 6472191 (2002-10-01), Yano et al.
patent: 6686439 (2004-02-01), Kenmoku et al.
patent: 6803444 (2004-10-01), Suzuki et al.
patent: 6825325 (2004-11-01), Fischer et al.
patent: 6853477 (2005-02-01), Nomoto et al.
patent: 6858417 (2005-02-01), Yano et al.
patent: 6861496 (2005-03-01), Kenmoku et al.
patent: 6864074 (2005-03-01), Yano et al.
patent: 6916861 (2005-07-01), Nomoto et al.
patent: 6951745 (2005-10-01), Nomoto et al.
patent: 7153622 (2006-12-01), Honma et al.
patent: 7235396 (2007-06-01), Nomoto et al.
patent: 2003/0194443 (2003-10-01), Yano et al.
patent: 2004/0005638 (2004-01-01), Honma et al.
patent: 2005/0208635 (2005-09-01), Nomoto et al.
patent: 2006/0115861 (2006-06-01), Shiotsuka et al.
patent: 2006/0172398 (2006-08-01), Nomoto et al.
patent: 2006/0172399 (2006-08-01), Nomoto et al.
patent: 2006/0275811 (2006-12-01), Hatakeyama et al.
patent: 2007/0054315 (2007-03-01), Imamura et al.
patent: 2007/0131546 (2007-06-01), Nomoto et al.
patent: 2007/0131547 (2007-06-01), Nomoto et al.
patent: 2007/0178522 (2007-08-01), Shiotsuka et al.
patent: 2007/0190590 (2007-08-01), Kubo et al.
patent: 88/06630 (1988-09-01), None
patent: 92/15606 (1992-09-01), None
patent: 93/15210 (1993-08-01), None
patent: 2004/003019 (2004-01-01), None
Miquel A. Andrade, et al., “Comparison of ARM and HEAT Protein Repeats”, J. Mol. Biol., vol. 309, 2001, pp. 1-18.
Mireille Dumoulin, et al., “A camelid antibody fragment inhibits the formation of amyloid fibrils by human Iysozyme”, Nature, vol. 424, Aug. 14, 2003, pp. 783-788.
Stefan Ewert, et al., “Biophysical Properties of Camelid VHHDomains Compared to Those of Human VH3 Domains”, Biochemistry, vol. 41, 2002, pp. 3628-3636.
Dario Neri, et al., “High-affinity Antigen Binding by Chelating Recombinant Antibodies (CRAbs)”, J. Mol. Biol., vol. 246, 1995, pp. 367-373.
Stewart D. Nuttall, et al., “Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop libraries”, Molecular Immunology, vol. 38, 2001, pp. 313-326.
Per-Åke Nygren, et al., “Binding proteins from alternative scaffolds”, Journal of Immunological Methods, vol. 290, 2004, pp. 3-28.
Erin K. O'Shea, et al., “Mechanism of Specificity in the Fos-Jun Oncoprotein Heterodimer”, Cell, vol. 68, Feb. 21, 1992, pp. 699-708.
Erin K. O'Shea, et al., “X-ray Structure of the GCN4 Leucine Zipper, a Two-Stranded, Parallel Coiled Coil”, Science, vol. 254, No. 5031, Oct. 25, 1991, pp. 539-544.
Mehmet Sarikaya, et al., “Molecular biomimetics: nanotechnology through biology”, Nature Materials, vol. 2, Sep. 2003, pp. 577-585.
Silvia Spinelli, et al., “Lateral Recognition of a Dye Hapten by a Llama VHH Domain”, J. Mol. Biol., vol. 311, 2001, pp. 123-129.
Katja M. Arndt, et al., “Helix-stabilized Fv (hsFv) Antibody Fragments: Substituting the Constant Domains of a Fab Fragment for a Heterodimeric Coiled-coil Domain”, Journal of Molecular Biology, vol. 312, No. 1, 2001, pp. 221-228.
Hong Seok Cheong, et al., “Affinity Enhancement of Bispecific Antibody Against Two Different Epitopes in the Same Antigen”, Biochemical and Biophysical Research Communications, vol. 173, No. 3, 1990, pp. 795-800.
Katja Els Conrath, et al., “Camel Single-domain Antibodies as Modular Building Units in Bispecific and Bivalent Antibody Constructs”, The Journal of Biological Chemistry, vol. 276, No. 10, Mar. 9, 2001, pp. 7346-7350.
Serge Muyldermans, “Single domain camel antibodies: current status”, Molecular Biotechnology, vol. 74, 2001, pp. 277-302.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Bispecific capturing molecule does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bispecific capturing molecule, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bispecific capturing molecule will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2646529

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.