Bispecific antibody determinants

Details Bispecific antibody determinants Bispecific antibody determinants

1990-12-05

1994-03-08

Chan, Y. Christina

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

435 18, 435 25, 43524027, 436548, 436819, 530344, 5303873, 5303905, 530408, G01N 3353, A61K 3514, C12Q 134, C12Q 128

Patent

active

052926680

ABSTRACT:
A homogenous sample of identical bispecific antibody determinants, each determinant being composed of two L-H half-molecules linked by disulfide bonds, each L-H half-molecule being specific for a different antigenic determinant and including at least the F(ab') portion of a monoclonal IgG antibody. The bispecific antibody determinants are useful, e.g., in the formation of multilamellar assemblies and in enzymatic assays.

REFERENCES:
patent: 4470925 (1984-09-01), Auditore-Hargreaves
patent: 4474893 (1984-10-01), Reading
Peabody, et al Biochemistry 19:2827 1980.
Masuho, et al BBRC 90:320 1979.

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