Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1997-11-12
2000-08-22
Burke, Julie
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241381, 4241441, 4241531, 4241551, 4241731, 4241741, 435328, 435330, 435334, 4353431, 435344, 435449, 435 711, 5303873, 5303877, 53038722, 53038873, A61K 39395, C12N 1506
Patent
active
061068330
ABSTRACT:
This invention relates generally to the field of immunology, in particular that of antibodies and antibody productions. More specifically, this invention relates to bispecific antibodies, the hybrid hybridomas which produce them, the parent hybridomas, the production and selection of the hybridomas and hybrid hybridomas, and the purification of the bispecific antibodies. Specific examples relate to bispecific monoclonal antibodies which recognize both the human multi-drug resistance antigen, P-glycoprotein and human Fc.gamma. receptor III (hFc.gamma.RIII). These bispecific antibodies are useful in killing cancer cells.
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Ring David
Shi Tian-Xiang
Alexander Lisa E.
Blackburn Robert P.
Burke Julie
Chiron Corporation
Robins Roberta L.
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