Bispecific and oligospecific mono-and oligovalent receptors, the

Details Bispecific and oligospecific mono-and oligovalent receptors, the Bispecific and oligospecific mono-and oligovalent receptors, the

1994-09-29

1997-01-07

Feisee, Lila

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

4351885, 5303897, 5303888, C07K 1646, C07K 1628

Patent

active

055918280

ABSTRACT:
The invention relates to bispecific and oligospecific, mono- and oligovalent receptors which are prepared by gene manipulation by fusion of DNA coding for F(ab) fragments of antibodies of two or more different specificities by means of suitable linkers. In this connection, one specificity is preferably directed either against an epitope, which is located on the cell membrane or in the interstitium, of a tumor-associated antigen (TAA) or against an epitope in the tumor endothelium (TE), while the other specificities relate to high-molecular or low-molecular weight ligands and react, for example, with the Komplexons ethylenediaminetetraacetate and diethylenetriaminepentaacetate in Y90 complexed form (EDTA-Y90 and DTPA-Y90 respectively). In a particularly preferred embodiment, the binding with the Komplexons takes place on the Komplexon receptor arm via fos-jun interaction (or else avidin-biotin interaction). Other preferred specificities have catalytic properties.

REFERENCES:
patent: 4652440 (1987-03-01), Paik et al.
patent: 4714681 (1987-12-01), Reading
H. Paulus, Behring Inst. Mitt. 78, (1985) 118-132.
U. D. Staerz and M. J. Bevan, Proc. Natl. Acad. Sci. USA 83, (1986) 1453-1457.
U. Zimmerman, Rev. Physio. Biochem. Pharmacol 105 (1986), 176-260.
J. Van Duk et al., Int. J. Cancer 43, (1989) 344-349.
M. W. Brechbiel et al., Inorganic Chemistry 25, (1986) 2772-2781.
Shulman et al., Nature 276, (1978) 269.
Cordell et al., J. Histochem. Cytochem. 32, (1984) 219.
Molecular Cloning, A Laboratory Manual; Sambrook, Fritsch, Maniatis; Cold Spring Harbor Laboratory, 1982, (S. 11-44, 51-127, 133-134, 141, 146, 150-167, 170, 188-193, 197-199, 248-255, 270-294, 310-328, 364-401, 437-506).
Molecular Cloning, A Laboratory Manual; Sambrook, Fritsch, Maniatis; Cold Spring Harbor Laboratory Press, 1989, (S. 16.2-16.22, 16.30-16.40, 16.54-16.55).
A. M. Frischauf et al., J. Mol. Biol. 170, (1983) 827-842.
G. H. A. Seeman et al., The EMBO Journal 5, (1986) 547-552.
Orlandi et al., Proc. Natl. Acad. Sci., USA 86, (1989) 3833-3837.
Simon et al., Nucl. Acids Res. 16, (1988) 354.
P. L. Ey et al., Immunochemistry 15, (1978) 429.
E. K. O'Shea et al., Science 245, (1989) 646-648.
J. P. Tam et al., J. Am. Chem. Soc. 105, (1983) 6442-6455.
J. Rivier et al., J. Chromatography 288, (1984) 303-328.
Beidler et al., The Journal of Immunology 141(11): 4053-60 (1988).
Williams, Trends in Biotechnology 6(2): 36-39, 42 (1988).
V. T. Oi & S. L. Morrison, Biotechnique 4(3): 214-21 (1986).
Tao et al. Journal of Immunology vol. 143 p. 2595 1989.
Osbund et al. Immunology Today, vol. 11, No. 6 p. 193 1990.
Waldmann, Science vol. 252 p. 1657 1991.
Harris et al. TibTech vol. 11 p. 42 1993.
Stanfield et al. TibTech vol. 12 1994 p. 275.
Hird et al. Genes and Cancer p. 183, 1990 ed. Carney and Sikora.
Lazar et al. Molecular and Cellular Biology p. 1247, 1988.
Gillies et al. Human Antibodies & Hybridomers 1(1) 1990 p.47.
Burgess et al. Journal of Cell Biology vol. 111 1990 p. 2129.
Huston et al. PNAS. vol. 85 5879, 1988.
Titus et al Journal of Immunology vol. 139 3153 N1 1987.

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