Chemistry of inorganic compounds – Treating mixture to obtain metal containing compound – Radioactive metal
Patent
1997-01-28
1998-05-05
Mai, Ngoclan
Chemistry of inorganic compounds
Treating mixture to obtain metal containing compound
Radioactive metal
423249, 376189, 210682, 210684, C01G 3000
Patent
active
057490422
ABSTRACT:
A method for separating .sup.213 Bi from a solution of radionuclides wherein the solution contains a concentration of the chloride ions and hydrogen ions adjusted to allow the formation of a chloride complex. The solution is then brought into contact with an anion exchange resin, whereupon .sup.213 Bi is absorbed from the solution and adhered onto the anion exchange resin in the chloride complex. Other non-absorbing radionuclides such as .sup.225 Ra, .sup.225 Ac, and .sup.221 Fr, along with HCl are removed from the anion exchange resin with a scrub solution. The .sup.213 Bi is removed from the anion exchange resin by washing the anion exchange resin with a stripping solution free of chloride ions and with a reduced hydrogen ion concentration which breaks the chloride anionic complex, releasing the .sup.213 Bi as a cation. In a preferred embodiment of the present invention, the anion exchange resin is provided as a thin membrane, allowing for extremely rapid adherence and stripping of the .sup.213 Bi. A preferred stripping solution for purification of .sup.213 Bi for use in medical applications includes sodium acetate, pH 5.5. A protein conjugated with bifunctional chelating agents in vivo with the NaOAc, to receive the .sup.213 Bi as it is being released from the anion exchange resin.
REFERENCES:
patent: 3758663 (1973-09-01), Kirby
patent: 4018561 (1977-04-01), Siemens et al.
patent: 4663129 (1987-05-01), Atcher et al.
patent: 5355394 (1994-10-01), van Geel et al.
Bray Lane Allan
DesChane Jaquetta R.
Battelle (Memorial Institute)
Mai Ngoclan
McKinley, Jr. Douglas E.
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