Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-12-03
2000-09-19
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514826, 514863, 564 49, 564 50, 564 51, C07C27918, A61K 3117
Patent
active
061213233
ABSTRACT:
Bishydroxyureas are provided that inhibit the enzyme 5-lipoxygenase. These compounds have the formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, A and M are defined herein. Also disclosed are pharmaceutical compositions containing such compounds and methods of inhibiting the enzyme 5-lipoxygenase using such compounds.
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K. A. Ohemeng et al., "Novel Bishydroxamic Acids as 5-Lipoxygenase Inhibitors", Bioorganic & Medicinal Chemistry, 2, No. 3, 187-193 (1994).
3M Innovative Properties Company
Howard MarySusan
O'Sullivan Peter
Ringsred Ted K.
Sprague Robert W.
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