Bisconjugates comprising two saccharides and a spacer

Details Bisconjugates comprising two saccharides and a spacer Bisconjugates comprising two saccharides and a spacer

1996-08-05

1998-01-06

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 514 61, 536 41, 536 172, 536 179, A61K 3170, C07H 1500

Patent

active

057054894

ABSTRACT:
The invention relates to a tuneable bisconjugate comprising two saccharides and a spacer, each saccharide being the same or different and comprising two to six monosaccharide units, at least one unit being uronic acid, characterized in that at least one of the saccharides per se has anti-thrombotic activity, and that the spacer connects at least one saccharide to the other through its non-reducing end, the chain length of the spacer being 20-120 atoms.

REFERENCES:
patent: 4818816 (1989-04-01), Petitou et al.
patent: 5008247 (1991-04-01), Meinetsberger
patent: 5037973 (1991-08-01), Meinetsberger
L. Rosenfeld et al., The Journal of Biological Chemistry, 263:1:262-266, 1988.
S. Radoff et al., The Journal of Biological Chemistry, 259:1:166-172, 1984.
CRC Handbook of Chemistry and Physics, 58th Edition, p. C-4, 1977-78.

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