Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reissue Patent
2007-05-15
2007-05-15
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S399000, C546S275100, C548S338100, C548S341500, C548S336100
Reissue Patent
active
10883195
ABSTRACT:
The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said compounds inhibiting fatty acid amide hydrolase and useful for the treatment of pain, particularly neuropathic pain, psychomotor disorder, hypertension, cardiovascular disease, eating disorder, nausea, AIDS-related complex, glaucoma, inflammation, psoriasis or multiple sclerosis, and other conditions the treatment of which can be effected by inhibiting fatty acid amide hydrolase.
REFERENCES:
patent: 5648373 (1997-07-01), Winkler et al.
Levine, “New Directions in Pain Research: Molecules to Maladies,” Neuron, vol. 20, pp. 649-654, Apr. 1998.
Pasternak, “The Central Questions in Pain Perception May Be Peripheral,” Proc. Natl. Acad. Sci., USA, vol. 95, pp. 10354-10355, Sep. 1998.
Devane, et al., “Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor,” Science, vol. 258, pp. 1946-1949, Dec. 18, 1992.
Hanus, et al., “Two New Unsatured Fatty Acid Ethanolamides in Brian That bind to the Cannabinoid Receptor,” J. Med. Chem., vol. 36, pp. 3032-3034, 1993.
Mechoulam, et al., “Identification of an Endogenous 2-Monoglyceride, Present in Canine Gut, That Binds to Cannabinoid Receptors,” Biochem. Pharmacol., vol. 50, No. 1, pp. 83-90, 1995.
Barg, et al., “Cannabinomimetic Behavioral Effects of and Adenylate Cyclase Inhibition by Two New Endogenous Anandamides,” European Journal of Pharmacology, vol. 287, pp. 145-152, 1995.
Richardson, et al., “Cannabinoids Reduce Hyperalgesia and Inflammation Via Interaction with Peripheral CB1 Receptors,” Pain, vol. 75, pp. 111-119, 1998.
Jaggar, et al., “The Anti-hyperalgesic Actions of the Cannabiniod Anandamide and the Putative CB2 Receptor Agonist Palmitoylethanolamide in Visceral and Somatic Inflammatory Pain,” Pain, vol. 76, pp. 189-199, 1998.
Huang, et al., “Identification of New Class of Molecules, the Arachidonyl Amide Acids, and Characterization of One Member That Inhibits Pain,” Journal of Biological Chemistry, vol. 276, No. 46, pp. 42639-42644, 2001.
Richardson, et al., “Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependant Hyperalgesia,” Journal of Neuroscience, vol. 18, No. 1, pp. 451-457, 1998.
Calignano, et al., “Control of Pain Initiation by Endogenous Cannabinoids,” Nature, vol. 394, pp. 277-280, Jul. 16, 1998.
Meng, et al., “An Analgesia Circuit Activated by Cannabinoids,” Nature, vol. 395, pp. 381-383, Sep. 24, 1998.
Meanwell, et al., “Nonprostanoid Prostacyclin Mimetics. 3. Structural Variations of the Diphenyl Heterocycle Molety,” Journal of Medicinal Chemistry, 1992, vol. 35, pp. 3498-3512.
Sit Sing-Yuen
Xie Kai
Bristol--Myers Squibb Company
Makujina Shah R.
Stockton Laura L.
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