Bisaryl derivatives having FSH modulatory activity

Details Bisaryl derivatives having FSH modulatory activity Bisaryl derivatives having FSH modulatory activity

2005-05-31

2005-05-31

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S385000, C544S374000, C544S377000, C544S379000, C544S179000, C544S182000, C540S492000, C540S527000, C548S319100, C548S550000, C546S216000, C560S027000, C564S056000, C564S153000, C514S218000, C514S212030, C514S327000, C514S392000, C514S424000, C514S487000, C514S595000, C514S252130, C514S254100, C514S254110, C514S616000

Reexamination Certificate

active

06900213

ABSTRACT:
The invention relates to bisaryl derivatives of the formula I,wherein (R,R) is selected from (H,H), O, (H,CH3), (H,OH) and (H,CN); Ar is substituted phenyland A is a group of formula II, III, IV or V:An example is (3S,6S)-1-N-(7-phenylheptyl)-3-(4-(3,4,5-trimethoxyphenyl)benzyl)-4-N-methyl-6-methyl-2,5-dioxo-1,4-piperazine:The compounds of the invention have FSH receptor modulatory activity and can be used for the control of fertility, for contraception or for treatment of hormone-dependent disorders.

REFERENCES:
patent: WO 00/08015 (2000-02-01), None
Guo et al. Bioorganic & Medicinal Chemistry Letters, vol. 14, p. 1717-1720 (2004).

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