Bisaryl cyclobutenes derivatives as cyclooxygenase inhibitors

Details Bisaryl cyclobutenes derivatives as cyclooxygenase inhibitors Bisaryl cyclobutenes derivatives as cyclooxygenase inhibitors

1997-03-11

1998-10-06

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Hydrocarbon doai

568 31, A61K 3110, C07C31710

Patent

active

058177000

ABSTRACT:
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

REFERENCES:
patent: 3335195 (1967-08-01), Freedman et al.
patent: 4967002 (1990-10-01), Pain
patent: 5077142 (1991-12-01), Sakon et al.
Lawson, et al, Journal of Medicinal Chemistry, vol. 17, No. 4, Apr. 1974 "Diarylcyclobutane Analogs of Diethylstilbestrol" pp. 383-386.
Friesen, R.W. et al.: Novel 1,2-diaxylcyclobutenes Selective and orally active CoX-2 inhibitors.
Bioorganic & Medicinal Chemistry Letters, vol. 6, No. 22, pp. 2677-2682, 1996.
Paull, K. D. et al. Cancer Res. vol. 52, No. 14, pp. 3892-3900 (1992).

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