Bisaryl COX-2 inhibiting compounds, compositions and methods of

Details Bisaryl COX-2 inhibiting compounds, compositions and methods of Bisaryl COX-2 inhibiting compounds, compositions and methods of

1999-02-09

1999-11-30

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514249, 514277, 514350, 514375, 514400, 514415, 514416, 514443, 514469, 514532, 514570, 514247, 544349, 544224, 546121, 546301, 546302, 546342, 548217, 5483101, 548470, 548510, 549 58, 549454, 560 9, 560 59, 560102, 562426, 562469, 562492, A61K 31425, A61K 3142, A61K 3138, A61K 3134, A61K 31215, A61K 3119, C07C32128, C07C 5964, C07C 5742, C07C 5738, C07D27764, C07D26356, C07D23506, C07D20944, C07D20918

Patent

active

059943793

ABSTRACT:
The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include pharmaceutically acceptable salts and esters thereof.

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Luong, Christine N., et al., Nature Structural Biology, vol. 3, pp. 927-933 (1996).

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