Bisalkoxyphosphinyl compounds as renin inhibitors

Details Bisalkoxyphosphinyl compounds as renin inhibitors Bisalkoxyphosphinyl compounds as renin inhibitors

1989-12-21

1992-09-22

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 548344, 548496, 562444, 562445, 562559, 562575, C07K 506, C07K 508

Patent

active

051496925

ABSTRACT:
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, glaucoma, and diseases caused by retroviruses including HTLV-I, -II, -III. Processes for preparing the peptides, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

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