Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1979-09-25
1981-05-12
Shaver, Paul F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
556404, A01N 5500, C07F 902, C07F 708
Patent
active
042671728
ABSTRACT:
The present invention presents a novel class of compounds bis(triorganosilylalkyl) phosphites, e.g. bis(trimethylsilylmethyl) phosphite. The compound is readily prepared by the reaction of a corresponding triorganosilyl alkanol with phosphorus trichloride or by the partial hydrolysis of a corresponding tris(triorganosilylalkyl) phosphite with an equimolar amount of water followed by distillation of the reaction mixture.
The compound has a remarkable anti-transplanted tumor effectiveness as established by the test with mice as the test animals for preventing the growth of Ehrlich's cancer cells and Sarcoma 180 cells. The compound has very low toxicity when orally administrated.
REFERENCES:
patent: 2864845 (1958-12-01), Kerschner et al.
patent: 3898257 (1975-08-01), Gregory
patent: 4089884 (1978-05-01), Shinohara et al.
Arai Masatoshi
Ito Koichi
Sato Ryuichi
Shinohara Toshio
Toyoshima Shigeshi
Shaver Paul F.
Shin-Etsu Chemical Co. , Ltd.
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