Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing
Reexamination Certificate
2008-10-10
2010-12-21
Price, Elvis O (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Silicon containing
C556S407000
Reexamination Certificate
active
07855300
ABSTRACT:
The present invention provides a compound that exhibits an excellent antitumor effect and reduces side effects, such as skin disorders, of the existing retinoid by selectively activating on the nuclear receptor RARα, thereby possibly producing significant improvement of clinical profits. Specifically, the present invention provides a bis(trimethylsilyl)phenyl compound represented by Formula (I):wherein X is N or CH; Y is O or S; R1, R2, and R3 are the same or different and are hydrogen or lower alkyl; R4 and R5 are the same or different and are hydrogen, lower alkyl, or halogen; and a bond between a carbon atom to which R1 is attached and a carbon atom to which R2 is attached is a single bond or a double bond;or a salt thereof.
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Murakami Koji
Oshiumi Hiromi
Suda Yoshimitsu
Price Elvis O
Rothwell Figg Ernst & Manbeck P.C.
Taiho Pharmaceutical Co. Ltd.
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