Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2010-08-30
2011-11-01
Kumar, Shailendra (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S422000
Reexamination Certificate
active
08048925
ABSTRACT:
Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I):Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1and R3taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2and R4taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Z is —O or —S. M+is a pharmaceutically acceptable monovalent cation and M2+is a pharmaceutically acceptable divalent cation.Also, disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt described above.
REFERENCES:
patent: 4012360 (1977-03-01), Schwarzenbach et al.
patent: 4822777 (1989-04-01), Abra
patent: 5498421 (1996-03-01), Grinstaff et al.
patent: 5560933 (1996-10-01), Soon-Shiong et al.
patent: 5665382 (1997-09-01), Grinstaff et al.
patent: 5739686 (1998-04-01), Naughton et al.
patent: 5840746 (1998-11-01), Ducharme et al.
patent: 5916596 (1999-06-01), Desai et al.
patent: 6013836 (2000-01-01), Hsu et al.
patent: 6096331 (2000-08-01), Desai et al.
patent: 6172108 (2001-01-01), Vega et al.
patent: 6172188 (2001-01-01), Thastrup et al.
patent: 6214863 (2001-04-01), Bissery et al.
patent: 6235787 (2001-05-01), Broadhurst et al.
patent: 6365745 (2002-04-01), Matsui et al.
patent: 6399659 (2002-06-01), Usui et al.
patent: 6435787 (2002-08-01), John
patent: 6455515 (2002-09-01), Gypser et al.
patent: 6506405 (2003-01-01), Desai et al.
patent: 6537579 (2003-03-01), Desai et al.
patent: 6656971 (2003-12-01), Wu et al.
patent: 6703426 (2004-03-01), Miles et al.
patent: 6749868 (2004-06-01), Desai et al.
patent: 6753006 (2004-06-01), Desai et al.
patent: 6762204 (2004-07-01), Koya et al.
patent: 6800660 (2004-10-01), Koya et al.
patent: 6825235 (2004-11-01), Chen et al.
patent: 6924312 (2005-08-01), Koya et al.
patent: 7001923 (2006-02-01), Koya et al.
patent: 7037940 (2006-05-01), Koya et al.
patent: 7074952 (2006-07-01), Chen et al.
patent: 7250432 (2007-07-01), Kwon et al.
patent: 7345094 (2008-03-01), Koya et al.
patent: 7368473 (2008-05-01), Koya et al.
patent: 7385084 (2008-06-01), Koya et al.
patent: 7435843 (2008-10-01), Chen et al.
patent: 7579503 (2009-08-01), Koya et al.
patent: 7795313 (2010-09-01), Koya et al.
patent: 2002/0198160 (2002-12-01), Everitt et al.
patent: 2004/0022869 (2004-02-01), Chen et al.
patent: 2004/0225016 (2004-11-01), Koya et al.
patent: 2004/0235813 (2004-11-01), Wanker et al.
patent: 2005/0154039 (2005-07-01), Glacera Contour
patent: 2006/0116374 (2006-06-01), Koya et al.
patent: 2006/0122183 (2006-06-01), Koya et al.
patent: 2006/0142386 (2006-06-01), Barsoum
patent: 2006/0142393 (2006-06-01), Sherman et al.
patent: 2006/0167106 (2006-07-01), Zhang et al.
patent: 2006/0270873 (2006-11-01), Chen et al.
patent: 2007/0088057 (2007-04-01), Lunsmann et al.
patent: 2008/0089950 (2008-04-01), Chen et al.
patent: 2008/0118562 (2008-05-01), Koya
patent: 2008/0119440 (2008-05-01), Koya
patent: 2008/0146842 (2008-06-01), Chen et al.
patent: 2008/0176828 (2008-07-01), Williams et al.
patent: 2008/0214655 (2008-09-01), Koya et al.
patent: 2008/0226588 (2008-09-01), McLeod
patent: 2008/0242702 (2008-10-01), Koya et al.
patent: 2008/0269340 (2008-10-01), Koya et al.
patent: 2009/0005594 (2009-01-01), Chen et al.
patent: 2009/0023736 (2009-01-01), Koya et al.
patent: 2009/0042991 (2009-02-01), Barsoum et al.
patent: 2009/0093538 (2009-04-01), Bertin et al.
patent: 2009/0137682 (2009-05-01), Dahl
patent: 2009/0281172 (2009-11-01), Koya et al.
patent: 2006/228035 (2006-11-01), None
patent: 2037257 (1972-02-01), None
patent: 1 454 628 (2004-09-01), None
patent: 1 493 445 (2005-01-01), None
patent: 1 406 869 (2006-09-01), None
patent: 1 731 148 (2006-12-01), None
patent: 2097737 (1972-04-01), None
patent: 1 272 920 (1972-05-01), None
patent: 50-91056 (1975-07-01), None
patent: 63-267752 (1988-11-01), None
patent: 07-165693 (1995-06-01), None
patent: 10-501215 (1998-02-01), None
patent: WO 94/10995 (1994-05-01), None
patent: WO 99/34796 (1999-07-01), None
patent: WO 03/006428 (2003-01-01), None
patent: WO 03/006429 (2003-01-01), None
patent: WO 03/006430 (2003-01-01), None
patent: WO 03/047524 (2003-06-01), None
patent: WO 2004/064826 (2004-08-01), None
patent: WO 2004/072051 (2004-08-01), None
patent: WO 2005/028475 (2005-03-01), None
patent: WO 2005/097758 (2005-10-01), None
patent: WO 2006/009940 (2006-01-01), None
patent: WO 2006/033913 (2006-03-01), None
patent: WO 2006/055747 (2006-05-01), None
patent: WO 2006/062732 (2006-06-01), None
patent: WO 2006/089177 (2006-08-01), None
patent: WO 2006/113493 (2006-10-01), None
patent: WO 2006/113572 (2006-10-01), None
patent: WO 2006/113695 (2006-10-01), None
patent: WO 2006/124736 (2006-11-01), None
patent: WO 2007/021881 (2007-02-01), None
patent: WO 2007/139955 (2007-12-01), None
patent: WO 2008/024298 (2008-02-01), None
patent: WO 2008/024299 (2008-02-01), None
patent: WO 2008/024301 (2008-02-01), None
patent: WO 2008/024302 (2008-02-01), None
patent: WO 2008/024303 (2008-02-01), None
patent: WO 2008/024305 (2008-02-01), None
patent: WO 2008/027445 (2008-03-01), None
patent: WO 2008/033300 (2008-03-01), None
patent: WO 2008/033449 (2008-03-01), None
patent: WO 2008/033494 (2008-03-01), None
patent: WO 2008/082579 (2008-07-01), None
patent: WO 2008/136976 (2008-11-01), None
patent: WO 2009/020631 (2009-02-01), None
patent: WO 2009/064374 (2009-05-01), None
patent: WO 2009/073147 (2009-06-01), None
patent: WO 2009/073148 (2009-06-01), None
Carter et al, Chemotherapy of Cancer, Wiley Medical Publication, John Wiley & Sons, 1981, 361-365.
Golub et al., “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring”,Science, vol. 286, 1999, pp. 531-537.
Bräuniger, H., “Hydrazide and Hydrazidderivate von Dicarbonsäuren,” Pharmaceutical-Chemical Institute of University of Fostock, Supplied by the “British Library” 25(5-6) 279-283 (1970).
Al-Talib, M. et al., “Diacyl Acid Dihydraides,”Magnetic Resonance in Chemistry, 28: 1072-1078 (1990).
Chuiguk, V.A. et al., “Mesoionic Methine Dyes of Biquaternary Salts of Diheteroaryl Methanes—Derivatives of 1,3,4-oxa (thia) Diazoles and 1, 2, 4-Triazoles,” Kiev. Gos. Univ., Kiev, USSR, Ukrainskii Khimicheskii Zhurnal, Russian Edition, 50(5): 519-524 (1984). Abstract, Accession No. 1984:6300420 HCAPLUS Database.
Barrett, W. G. et al., “Decomposition and Cycloaddition Reactions of Some Bis(azodicarbonyl) Compounds,”Journal of Chem. Soc. (4): 1046-1052 (1975).
Mitsui Toatsu Chem. Inc., Abstract of Japanese Patent No. 308024, published Dec. 25, 1986. from Derwent Publications Ltd. Honshu Paper Mfg. Co. Ltd.
Honshu Paper Mfg. Co. Ltd, Abstract of Japanese Patent No. 182050, published Feb. 13, 1996.
Molina, P. et al., XP-01118868, “Methyl 2-Methyldithiocarbazate in Heterocyclic Synthesis: Preparation of 2,5-Disubstituted 1,3,4-Thiadiazoles, Bis(1,3,4-Thiadiazolium) Salts and Macrocycles Containing 1,3,4-Thiadiazole Subunits, X-Ray Crystal Structure of 2,2′-Bis[4,5-dihydro-5-(2-hydroxyethylimino)-4-methyl-1,3,4-thiadiazole],”J. Chem. Soc. Perkin Trans. 1s, 5: 1159-1166 (1991).
Molina, P. et al., XP-001118802, “Preparation of a Novel Type of Ligands Incorporating Two or Three 1,3,4-Thiadiazole Units,”Heterocycles, 36(6): 1263-1278 (1993).
Chuyguk, V. A. and Nemazanyj A.G., “Mesoionic Methine Dyes from Biquaternary Salts of Dihetarylmethanes—1,3,4-Oxa(thia)diazoles and 1,2,4-Triazoles Derivatives,”Ukr. Khim. Zhurn. 48:520 (1984).
“Remarks” paper as submitted by Applicant's Attorney.
Stalter
Chen Shoujun
Inoue Takayo
Kostik Elena
Koya Keizo
Liang Guiqing
Davis Steven G.
Kumar Shailendra
McCarter & English LLP
Synta Pharmaceuticals Corp.
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