Bis(thio-hydrazide amide) salts for treatment of cancers

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C514S422000, C514S599000, C548S518000

Reexamination Certificate

active

07385084

ABSTRACT:
Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I):Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1and R3taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2and R4taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Z is —O or —S. M+is a pharmaceutically acceptable monovalent cation and M2+is a pharmaceutically acceptable divalent cation.Also, disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt described above.

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