Bis-tetrazolmethyl substituted .beta.-lactam antibiotics

Details Bis-tetrazolmethyl substituted .beta.-lactam antibiotics Bis-tetrazolmethyl substituted .beta.-lactam antibiotics

1980-09-17

1981-12-08

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424852, 542418, 544 90, A61N 31535, C07D49804

Patent

active

043047742

ABSTRACT:
Broad spectrum .beta.-lactam antibiotics represented by the formula ##STR1## wherein R is the residue of a carboxylic acid, R.sub.2 is H or OCH.sub.3, and R.sub.4 is hydrogen or C.sub.1 -C.sub.3 alkyl; are obtained by reacting a 7-acylamino-3-halomethyl-1-oxa-.beta.-lactam ester with the desired 1- or 2-tetrazolemethyl substituted 1H or 2H tetrazole-5-thiol. Alternatively, a 7-amino-3-halo-methyl-1-oxa-.beta.-lactam ester is first reacted with the bis-tetrazole thiol and then the product is N-acylated with the desired carboxylic acid.

REFERENCES:
patent: 4138486 (1979-02-01), Narisada et al.
patent: 4226866 (1980-10-01), Christensen et al.
patent: 4232151 (1980-11-01), Nagata et al.

Affiliated with

Also associated with

Rating

Bis-tetrazolmethyl substituted .beta.-lactam antibiotics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bis-tetrazolmethyl substituted .beta.-lactam antibiotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bis-tetrazolmethyl substituted .beta.-lactam antibiotics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-567826