Bis-sulfonamides hydroxamic acids as MMP inhibitors

Details Bis-sulfonamides hydroxamic acids as MMP inhibitors Bis-sulfonamides hydroxamic acids as MMP inhibitors

1998-01-09

1999-01-12

Nazario-Gonzalez, Porfirio

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562623, A01N 3728

Patent

active

058590617

ABSTRACT:
The present invention provides a compound of formula I ##STR1## or pharmaceutically acceptable salts thereof wherein R.sup.1 and R.sup.2 are the same or different and are C.sub.1-10 alkyl, phenyl, hetero-aryl, or phenyl substituted with C.sub.1-4 alkyl, OR.sup.3, NHR.sup.3, CONHR.sup.3, NHCOR.sup.3, or halo; wherein R.sup.3 is H, or C.sub.1-4 alkyl; and n is 1, 2, 3, 4, 5, or 6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.

REFERENCES:
patent: 5506242 (1996-04-01), MacPherson et al.
patent: 5552419 (1996-09-01), MacPherson et al.
U.S. application Ser. No. 60/029,585, M. Warpehoski, et al., Oct. 23, 1996.

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