Bis-quaternary pyridinium-2-aldoxime salts and a process for the

Details Bis-quaternary pyridinium-2-aldoxime salts and a process for the Bis-quaternary pyridinium-2-aldoxime salts and a process for the

1977-04-11

1978-12-05

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424266, 544331, 544296, 546262, 546263, A61K 3144, A61K 31455, C07D21378

Patent

active

041286510

ABSTRACT:
Bis-quaternary pyridinium-2-aldoxime salts of the formula ##STR1## wherein R is --CO--R.sup.1, --CO--NR.sup.2 R.sup.3 or --COOR.sup.4 ; R.sup.1 is alkyl of 1 - 6 carbon atoms, cyclohexyl, Ar or benzyl; R.sup.2 is H, alkyl of 1 - 6 carbon atoms, cyclohexyl, Ar, aralkyl of 7 - 13 carbon atoms or 2-pyrimidyl; R.sup.3 is alkyl of 2 - 6 carbon atoms, cyclohexyl, Ar, aralkyl of 7 - 13 carbon atoms or 2-pyrimidyl; R.sup.4 is alkyl of 2 - 6 carbon atoms, cyclohexyl, Ar or benzyl; Ar is phenyl or phenyl monosubstituted or polysubstituted by alkyl of 1 - 4 carbon atoms, methoxy, Cl, or naphthyl and X is Cl, Br or I, are antidotes for phosphorus-containing pesticides and chemical warfare agents.

REFERENCES:
patent: 3773775 (1973-11-01), Hagedorn

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