Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing
Patent
1992-05-26
1993-02-09
Mars, Howard T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Silicon containing
556436, 560193, 560106, 560231, 568660, C07F 708, C07C 4313, C07C 6934
Patent
active
051854597
ABSTRACT:
Cyclobutanols of the formula ##STR1## wherein P is a hydroxy protecting group are useful intermediates in the preparation of antiviral compounds.
REFERENCES:
patent: 3379770 (1968-04-01), Elam et al.
patent: 4177348 (1979-12-01), Shealy et al.
patent: 4232154 (1980-11-01), Shealy et al.
patent: 4617304 (1986-10-01), Ashton et al.
patent: 4743689 (1988-05-01), Shimada
patent: 4782062 (1988-11-01), Tolman et al.
patent: 4801710 (1989-01-01), Mac Coss et al.
patent: 4855466 (1989-08-01), Zahler et al.
patent: 4918075 (1990-04-01), Zahler et al.
patent: 4968674 (1990-11-01), Taniyama et al.
patent: 5064961 (1991-11-01), Bisacchi et al.
Peterson et al., "The Chemistry of Photodimers of Maleic and Furmaic Acid Derivatives", The Journal of Organic Chemistry, vol. 33, pp. 1018-1021 (1968).
N. Shimada et al., Oxetanocin, A Novel Nucleoside from Bacteria, Nov. 1986, J. Antibiotics 39, p. 1623.
H. Nakamura et al., The X-Ray Structure Determination of Oxetanocin, Nov. 1986, J. Antibiotics, 39, p. 1626.
H. Hoshino et al., Inhibition of Infectivity of Human Immunodeficiency Virus by Oxetanocin, Jul. 1987, J. Antibiotics, 40, p. 1077.
S. Niitsuma et al., Studies on the Total Synthesis of Oxetanocin; Tetrahedron Letters, vol. 28, pp. 4713-4714, May 1987.
G. N. Austin et al., Chiral Oxetanes from Sugar Lactones, Tetrahedron Letters, vol. 28, pp. 4741-4744, May 1987.
N. Shimada et al.--Derivatives of Oxetanocin: Oxetanocins, H, X and G, and 2-Aminooxetanocin A, J. Antibiotics, vol. 40, p. 1789, Dec. 1987.
Walton, "3-Methylenecyclobutyl, Cyclopent-3-enyl . . . ", J.Chem.Soc. Perkin Trans II 1987 pp. 231-235.
Kirmse et al., "2-Oxabicyclo[2.1.1]hexan . . . ", Chemische Berichte, vol. 121, No. 5, 1988, pp. 1013-1016.
Hanack et al., "Solvolysan von delta.sup.2 -cyclobutylmethyltosylat", Chemische Berichte, vol. 100, No. 6, 1967, pp. 2107-2116.
DeClerq, "Pyrimidine Nucleoside Analogs As Antiviral Agents" Targets For The Design of Antiviral Agents, 1983, pp. 203-230.
Bamford et al., "Synthesis and Antiviral Acitivty . . . " J. Med. Chem., 1990, vol. 33, pp. 2494-2501.
Kono et al., "Substrate Specificity Of A Thymidine . . . " Chem. Pharm. Bull., vol. 32 (1984), pp. 1919-1921.
March, "Advanced Organic Chemistry", 1985, p. 129.
Niitsuma et al., "Studies On The Total Synthesis . . . " Tetrahedron Letters, vol. 28, pp. 3967-3970 (1987).
Marquez et al., "Carbocyclic Nucleosides", Medicinal Research Review, vol. 6, pp. 1-16 and 36-40.
Shealy et al., "Synthesis and Antiviral Activity . . . ", J. Med. Chem., vol. 27, pp. 1416-1421 (1984).
Slusarchyk William A.
Zahler Robert
Davis Stephen B.
E. R. Squibb & Sons Inc.
Mars Howard T.
Page Margaret J.
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