Bis-platinum complexes as chemotherapeutic agents

Details Bis-platinum complexes as chemotherapeutic agents Bis-platinum complexes as chemotherapeutic agents

1986-07-25

1989-01-10

Shaver, Paul F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514187, 514492, 546 5, 546 6, 556 24, 556137, C07F 1500

Patent

active

047973935

ABSTRACT:
A bis-platinum complex having the structure: ##STR1## wherein X and Y are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate or dicarboxylate. B and C are the same or different and are primary or secondary amines, or pyridine type nitrogens. A is a diamine or polyamine wherein the primary amine N atoms are coordinated to the Pt atom such that platinum is present as Pt.sup.2+. The complexes are useful in the inhibition of tumors.

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Kuroda et al., Inorg. Chem., 22, 3620 (1983).
Pasini et al., Inorg. Chim. Acta., 93, 167 (1984).

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