Bis-platinum complexes as chemotherapeutic agents

Details Bis-platinum complexes as chemotherapeutic agents Bis-platinum complexes as chemotherapeutic agents

1989-09-01

1992-04-21

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556136, C07F 1500

Patent

active

051070073

ABSTRACT:
A bis(platinum) complex having the structure: ##STR1## wherein X, Y, Z, X', Y', and Z' are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate, dicarboxylate, substituted dicarboxylate primary or secondary amine, sulfoxide, phosphine, pyridine-type nitrogen and the like; preferably, there is at least one Pt-anion bond on each Pt molecule; and A is a diamine or polyamine.
Complexes of trans geometry [PtX.sub.2 (L)(L')] where at least L is a planar ligand such as pyridine but preferably quinoline and L' may be amine, sulfoxide or substituted sulfoxide and X is a chloride, nitrate or carboxylate.
A process for obtaining bis(platinum) complexes where the two platinum coordination spheres may contain different ligands in each sphere and where the geometry of each platinum coordination sphere may be the same or different.

REFERENCES:
patent: 4533502 (1985-08-01), Rochon et al.
patent: 4560782 (1985-12-01), Papageorgiou et al.
patent: 4565884 (1986-01-01), Andrulis, Jr. et al.
patent: 4730069 (1988-03-01), Kolar et al.
patent: 4797393 (1989-01-01), Farrell et al.

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