Bis-platinum complexes as antitumor agents

Details Bis-platinum complexes as antitumor agents Bis-platinum complexes as antitumor agents

1984-05-10

1986-01-21

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

534661, 534662, 534683, 534684, 536121, 544301, 556 19, 548106, 514492, 534722, 534841, C07F 1500

Patent

active

045658846

ABSTRACT:
Bis-platinum complexes having the formula ##STR1## wherein A is a ligand having two pairs of platinum-coordinating acidic groups which are each independently a carboxylate, phenolate, sulfonate or phosphonate group, each said pair being capable of coordinating with a platinum ion to form a 5-10 membered chelate ring; Z is a water-solubilizing group; n is 0 or a positive integer, with the proviso that n is 0 only when at least one of said platinum-coordinating acidic groups is sulfonate or phosphonate or when at least one platinum ion is a Pt(IV) ion; and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are each independently H or a C.sub.1-20 alkyl, aryl, aralkyl, or alkaryl group, or together form one or more C.sub.1-30 alkylene, cycloalkylene, arylene, aralkylene or alkarylene groups; or a pharmaceutically acceptable salt thereof, are useful as readily water-soluble antitumor agents.

REFERENCES:
patent: 4115418 (1978-09-01), Gale et al.
patent: 4119653 (1978-10-01), Tobe et al.
patent: 4137248 (1979-01-01), Gale et al.
patent: 4169846 (1979-10-01), Kidani et al.
patent: 4200583 (1980-04-01), Kidani et al.
patent: 4225529 (1980-09-01), Hydes et al.
patent: 4230631 (1980-10-01), Hydes et al.
patent: 4250189 (1981-02-01), Hydes et al.
patent: 4255347 (1981-03-01), Kidani et al.
patent: 4256652 (1981-03-01), Kidani et al.
patent: 4271085 (1981-06-01), Amundsen et al.
patent: 4283342 (1981-08-01), Yolles
patent: 4322362 (1982-03-01), Kaplan et al.
patent: 4359425 (1982-11-01), Totani et al.
patent: 4410544 (1983-10-01), Berg et al.
patent: 4452812 (1984-06-01), Macquet
Rochon et al, J. of Clinical Hematology and Oncology, vol. 12, No. 2, pp. 39-43 (1982).

Affiliated with

Also associated with

Rating

Bis-platinum complexes as antitumor agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bis-platinum complexes as antitumor agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bis-platinum complexes as antitumor agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2299372