Bis(morpholinomethyl) derivative of 1,2-bis(dioxopiperizinyl)pro

Details Bis(morpholinomethyl) derivative of 1,2-bis(dioxopiperizinyl)pro Bis(morpholinomethyl) derivative of 1,2-bis(dioxopiperizinyl)pro

1988-09-28

1990-08-21

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D41312

Patent

active

049507559

ABSTRACT:
Bis(morpholinomethyl) derivative of 1,2-bis(dioxopiperizinyl)propane of the formula: ##STR1## wherein R is CH.sub.3, R' is ##STR2## and the process for the synthesis thereof is provided. The compound of the present invention is water soluble, may be administered by intravenous injection and lessens the severity of doxorubicin-induced cardiotoxicity.

REFERENCES:
Ren et al., Kexue Tongbao, 1980:25, 189.
Chemical Abstracts vol. 102 (1985) No. 149288g (Abstract of JP59, 190 976, 29 Oct. 1984).

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