Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-02-09
1998-08-18
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514311, 514312, 514313, 514314, 544128, 544363, 546153, 546155, 546159, 546160, 546167, 546171, 546173, 546176, 546178, A61K 3147, A61K 31495, A61K 31535, C07D21516
Patent
active
057958890
ABSTRACT:
This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferation comprising the administration thereto of an EGF and/or PDGF receptor inhibiting effective amount of said bis mono- and/or bicyclic aryl and/or heteroaryl compound and to the preparation of said compounds and their use in pharmaceutical compositions used in this method.
REFERENCES:
patent: 3272824 (1966-09-01), Ebetino et al.
patent: 3715358 (1973-02-01), Witzel et al.
patent: 3718743 (1973-02-01), Shen et al.
patent: 3985749 (1976-10-01), Foster
patent: 4322420 (1982-03-01), Kobayashi et al.
patent: 4464375 (1984-08-01), Kobayashi et al.
patent: 4465686 (1984-08-01), Lesher et al.
patent: 4599423 (1986-07-01), Lesher et al.
patent: 4661499 (1987-04-01), Young et al.
patent: 5134148 (1992-07-01), Crawley et al.
Tetrahedron, vol. 38, No. 22, pp. 3347-3354 (1982), Tamao et al., Nickel-Phosphine Complex-Catalyzed Grignard Coupling--II Grignard Coupling of Heterocyclic Compounds, English Original.
Synthesis, pp. 564-565 (Jul. 1986), Yamamoto et al., General Method for Synthesis of Bipyridines: Palladium Catalyzed Cross-Coupling Reaction of Trimethylstannylpyridin, English Original.
Chem. Pharm. Bull., vol. 30, No. 6, pp. 2003-2010 (1982), Yamamoto et al., Studies on Organometallic Compounds. III. Reaction of Trimethylstannylazines with Acyl Chlorides. A, English Original.
Heterocycles, vol. 23, No. 9, pp. 2375-2386 (1985), Ishikura et al., A Simple and Regioselective Preparation of 2-or 3-Substituted Quinoline Derivatives Via Dialkylquinolylboranes, English Original.
J. Am. Chem. Soc., vol. 111, No. 3, pp. 877-891 (1989), Stern et al., Potential-Dependent Surface Chemistry of 3-Pyridinecarboxylic Acid (Niacin) and Related Compounds at Pt(111) Electrodes, English Original.
Chemical Abstract, vol. 84:164632t, p. 453 (1976), Yoshina, Quinoline Derivatives, English Abstract.
Chemical Abstract, vol. 103:123292z, p. 709 (1985), Barker et al., Dehalogenation of 1-Halothienyldi-and -Tetrahydroisoquinolines by Sodium Methoxide in Dimethyl Sulfoxide, English Abstract.
Chemical Abstract, vol. 108:55860j, p. 704 (1988), Epling et al., Sulfur-Containing 2-Aryquinolinemethano Is as Potential Antimalarials, English Abstract.
J. Heterocyclic Chem., vol. 20, pp. 1739-1740 (1983), Saeed et al., Preparation of Phenylquinoxaline from alpha,alpha-Diaminoketones and Dimethyl-o-phenylenediamine, English Original.
Maguire Martin P.
Myers Michael R.
Persons Paul E.
Spada Alfred P.
Cebulak Mary C.
Dees Jos,e G.
Nicholson James A.
Parker III Raymond S.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
LandOfFree
Bis mono- and bicyclic aryl and heteroaryl compounds which inhib does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bis mono- and bicyclic aryl and heteroaryl compounds which inhib, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bis mono- and bicyclic aryl and heteroaryl compounds which inhib will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1114968