Bis-modified bicyclic nucleic acid analogs

Details Bis-modified bicyclic nucleic acid analogs Bis-modified bicyclic nucleic acid analogs

2008-12-09

2010-02-23

Lewis, Patrick T (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S042000, C514S043000, C536S022100

Reexamination Certificate

active

07666854

ABSTRACT:
The present disclosure describes bis-modified bicyclic nucleosides and oligomeric compounds that can be prepared comprising at least one of these bis-modified bicyclic nucleosides. More particularly, the bis-modified bicyclic nucleosides have at least one substituent group at the 5′-methylene and on the bridge methylene and can be chiral. These bis-modified bicyclic nucleosides are expected to be useful for enhancing one or more property of oligomeric compounds including for example enhancing nuclease resistance.

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