Bis-methylene ether pyridinium compound preparation

Details Bis-methylene ether pyridinium compound preparation Bis-methylene ether pyridinium compound preparation

1985-11-20

1992-07-14

Maples, John S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546264, C07D21344, C07D21336

Patent

active

051304384

ABSTRACT:
An illustrative embodiment of the invention substitutes solid, non-carcinogenic bis(methanesulfonoxymethyl) ether for bis-chloromethyl ether in a low temperature reaction of about 0.degree.-5.degree. C. for the production of bis-methylene ether pyridinium quaternary compounds. In this way, the production of important nerve agent antidotes (toxogonin, HI-6 and HGG-12) by a method of synthesis using the reactant bis-mesylmethyl ether, is carried out in appreciably greater safety.

REFERENCES:
patent: 3962447 (1976-06-01), Higuchi et al.
patent: 4128651 (1978-12-01), Hagedorn
patent: 4352810 (1982-10-01), Benschop et al.
Burness et al., "Bis(methylsulfonoxymethyl)ester" J. Org Chem vol. 42, No. 7, 1977, pp. 2910-2913.

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