Bis-indole pyrroles useful as antimicrobials agents

Details Bis-indole pyrroles useful as antimicrobials agents Bis-indole pyrroles useful as antimicrobials agents

2007-01-23

2007-01-23

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S453000, C548S455000

Reexamination Certificate

active

11040923

ABSTRACT:
Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

REFERENCES:
patent: 5445829 (1995-08-01), Paradissis et al.
patent: 5576012 (1996-11-01), Bauer et al.
patent: 5641515 (1997-06-01), Ramtoola
patent: 5653987 (1997-08-01), Modi et al.
patent: 5654286 (1997-08-01), Hostetler
patent: 5667809 (1997-09-01), Trevino et al.
patent: 5683676 (1997-11-01), Akehurst et al.
patent: 5688529 (1997-11-01), Lidgate et al.
patent: 5707615 (1998-01-01), Cardin et al.
patent: 5707641 (1998-01-01), Gertner et al.
patent: 5726181 (1998-03-01), Hausheer et al.
patent: 5733888 (1998-03-01), Carver et al.
patent: 5874443 (1999-02-01), Kiely et al.
patent: 5886210 (1999-03-01), Rayle et al.
patent: 5922683 (1999-07-01), Or et al.
patent: 6350759 (2002-02-01), Casara et al.
patent: 6500825 (2002-12-01), Lan et al.
patent: 6506787 (2003-01-01), Fujishita et al.
patent: 6509331 (2003-01-01), Audia et al.
patent: 6569830 (2003-05-01), Climo et al.
patent: 6589977 (2003-07-01), Sodeoka et al.
patent: 0 612 742 (1994-08-01), None
patent: 1 057 484 (2000-12-01), None
patent: 1 152 002 A1 0 (2001-11-01), None
patent: 1 352 906 (2003-10-01), None
patent: WO 91/04975 (1991-04-01), None
patent: WO 00/33836 (2000-06-01), None
patent: WO 02/055725 (2002-07-01), None
patent: WO 02/057254 (2002-07-01), None
patent: WO 02/068424 (2002-09-01), None
Adrian, P.V. et al., Antimicrob Agents Chemother, 44:3101 (2000).
Alm et al., Prog. Clin. Biol. Res., 312:447-58 (1989).
Buchanan, Malcom S., et al., Phytochemistry 41(3):791-793, (1996).
Bull, A.T. et al., Microbiol Mol Biol Rev 64:573, (2000).
Choe, C.H. et al., Antimicrob Agents Chemother 44:1766 (2000).
Cragg, G.M. & D.J. Newman, Trends Pharmacol Sci 23:404, (2002).
Eliopoulos, G.M. & C.B. Wennersten, Antimicrob Agents Chemother 46:1319 (2002).
Faulkner, D.J , Nat Prod Rep 18:1, 2001.
Fingl et al., in The Pharamacological Basis of Therapeutics, (1975).
Frode et al. Tetrahedron Lett. 35:1689-1690 (1994), related document, not cited.
Grayson, M (Ed.) “Antibiotics, Chemotherapeutics and Antibacterial Agents for Disease Control”, (1982).
Hashimoto et al., Tetrahedron Letters 35:2559-2560 (1994).
Hashimoto, T. et al., “Structures of new polyacetylene triglycerides and indolocarbazoles from the myxomycetes Lycogala epidendrum” Tennen Yuki Kagobutsu Toromnkai Koen Yoshishu 34th, 470-477 (1992).
Higuchi T. and Stella, V., “Pro-drugs as Novel Delivery Systems”, vol. 14, A.C.S. Symposium Series, American Chemical Society (1975).
Hoellman, D.B. et al., Antimicrob Agents Chemother 42:857, (1998).
Hoshino et al. Biosci, Biotech, Biochem, 57, 775-781 (1993), related but not cited.
Joshi, A., J Ocul Pharmacol 10:29-45, (1994).
Kerr, R.G. & S.S. Kerr, Exp Opin Ther Patents 9:1207, (1999).
Mayer et al., Ophthalmologica, 210(2):101-3 (1996).
Mayer, A. M. & V.K. Lehmann, Anticancer Res 21:2489, (2001).
Moore, B.S, Nat Prod Rep 16:653, (1999).
Mordenti, Toxicol. Sci., 52(1):101-6 (1999).
Okami, Y., J Mar Biotechnol 1:59, (1993).
Onaka, Characeterization of the Biosynthetic Gene Cluster of Rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243. Biosci.Biotechnol.Biochem., 67 (1), 127-138, (2003), cited p. 133, Line 3.
Remington's Pharmaceutical Sciences, 18th Ed., Mack Publishing Co., Easton, PA(1990).
Roche E.B. (Ed.) “Bioreversible Carriers in Drug Design: Theory and Application”, Pergamon Press: New York, 14-21 (1987).
Sánchez, Combinatorial biosynthesis of antitumor indolocarbazole compounds. PNAS vol. 102 No. 2, 461-466, (Jan. 11, 2005).
Shedden et al., Clin. Ther., 23(3):440-50, (2001).

Affiliated with

Also associated with

Rating

Bis-indole pyrroles useful as antimicrobials agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bis-indole pyrroles useful as antimicrobials agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bis-indole pyrroles useful as antimicrobials agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3729018