Bis-indole imidazole compounds which are useful antitumor and an

Details Bis-indole imidazole compounds which are useful antitumor and an Bis-indole imidazole compounds which are useful antitumor and an

1989-10-03

1990-11-13

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548336, A61K 31415

Patent

active

049702262

ABSTRACT:
Novel brominated bisindole-imidazole alkaloids have been isolated from marine sponges. These compounds, and derivatives thereof, are useful antimicrobial and antitumor compounds.

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Norton, R. S., and R. J. Wells (1982) "A Series of Chiral Polybrominated Bindoles from the Marine Blue-Green Alga Rivularia firma, Application of .sup.13 C NMR Spin-Lattice Relaxation Data and .sup.13 C-.sup.1 H Coupling Constants to Structure Elucidation," J. Am. Chem. Soc. 104:3628-3635.
Bartik, K. et al., (1987) "Topsentins, New Toxic Bis-Indole Alkaloids from the Marine Sponge Topsentia genitrix," Can. J. Chem. 65:2118-2121.
Braekman, J. C. et al., (1987) "Synthesis of Topsentin-A, a Bisindole Alkaloid of the Marine Sponge Topsentia genitrix," Bull. Soc. Chim. Belg. 96(10):809-812.

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