Bis-indole-alkaloid

Details Bis-indole-alkaloid Bis-indole-alkaloid

1979-07-27

1981-11-03

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424262, C07D51904

Patent

active

042985250

ABSTRACT:
A process for the preparation of diindolealkaloids, especially new compounds corresponding to vinblastine or leurosine, in which the N-methyl group is replaced by an N--CH.sub.2 --OC.sub.2 H.sub.5 group having antitumor properties. The starting compounds are subjected to oxidation by chromic acid or an alkali metal dichromate at temperatures from -90.degree. C. to -30.degree. C. but preferably below about -45.degree. C. when the new compounds are to be produced, ethanol being present in this case.

REFERENCES:
patent: 3097137 (1963-07-01), Beer
patent: 3205220 (1965-09-01), Suoboda
patent: 3354163 (1967-11-01), Gorman
patent: 3370057 (1968-02-01), Suoboda
patent: 3899493 (1975-08-01), Jovanovics
patent: 4189432 (1980-02-01), Jovanovics et al.

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