Bis-hydrazones of daunomycin and adriamycin

Details Bis-hydrazones of daunomycin and adriamycin Bis-hydrazones of daunomycin and adriamycin

1977-09-02

1978-09-05

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 17, C07G 300

Patent

active

041122178

ABSTRACT:
Bis-hydrazones of daunomycin and adriamycin having useful antitumor characteristics and the structure ##STR1## WHEREIN N IS AN INTEGER HAVING A VALUE OF FROM 0 THROUGH 8 AND THE RADICALS INDICATED BY R and R' each represent hydrogen except that in those instances in which n has a value of 2, the R groups, if not hydrogen, may be methyl radicals (with R' remaining as hydrogen), and the R' groups, if not hydrogen, may be hydroxy radicals (with R remaining as hydrogen).

REFERENCES:
patent: 3957755 (1976-05-01), Jolles
patent: 3965088 (1976-06-01), Jolles
Jolles et al., Chemotherapy, vol. 8, Cancer Chemotherapy II, Plenum Press, New York and London (1975), pp. 237-241, (Chem. Abstracts 86:182689m).

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