Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibito

Details Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibito Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibito

1996-02-06

1997-11-25

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514249, 514367, 544353, 546152, 546174, 548156, A61K 3147, C07D40112

Patent

active

056913516

ABSTRACT:
Compounds having the structure ##STR1## where m is an integer of from one to nine; n is an integer of from one to four; W is selected from substituted or unsubstituted quinolyl, benzothiazolyl, or quinoxalyl, X is selected from C.sub.1-6 alkylene, C.sub.2-6 alkenylene and C.sub.2-6 alkynylene; Y is selected from halogen, C.sub.1-6 alkyl and C.sub.1-6, alkoxy; and Z is selected from --C(O)B; --C(R.sub.2).sup.2 --O--N.dbd.A--C(O)B; and --C(R.sup.2).dbd.N--O--A--C(O)B where A is C.sub.1-6 alkylene and B is --OH, --O--M.sup.+, --OD where D is a metabolically cleavable group, --OR.sup.6 where R.sup.6 is hydrogen or C.sub.1-6 alkyl, --NR.sup.6 R.sup.7 where R.sup.7 is hydrogen, C.sub.1-6 alkyl, hydroxy or C.sub.1-6 alkoxy, or where R.sup.6 and R.sup.7 taken together form a five to eight membered ring optionally containing one heteroatom selected from nitrogen, oxygen or sulfur, are inhibitors of leukotriene biosynthesis.

REFERENCES:
Cope, et al., cis,cis-1,5-Cyclooctadiene Diepoxide, The Journal of Organic Chemistry, vol. 84, No. 7, Jul., (1989), pp. 2231-2234.
von Leander Tenud, et al., 1,3-Cyclobutandionderivate aus Keten, Helvetica Chimica Acta, vol. 60, Fasc. 3,, (1977)--Nr. 100, pp. 975-977.
McIntosh, J. M., An Improved Preparation of 1,3-Cyclopentanedione, J. Org. Chem, vol. 37. No. 18, (1972), pp. 2905-2906.
Dowd, P., et al., Novel Free Radical Ring-Expansion Reaction, Tetrahedron, vol. 45, No.1, (1989), pp. 77-90.
Bashir-Hashemi, A., et al., Regioselectivity in Photochemical Chlorocarbonylation of Carbonyl Compounds, J. Org. Chem, vol. 59, No. 8, 1994, pp. 2132-2134.
Curran, D. P., et al., Tandem Transannular Radical Cyclizations. Total Synthesis of (+/-)-Modhephene and (+/-)-Epi-Modhephane, Tetrahedron, vol. 49, No. 4, 1993, pp. 755-770.
Miur, H., et al., Synthese von 5-substituierten Cyclooctynen, Communications, Aug., 1978, pp.596-598.

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