Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-04-04
2006-04-04
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S455000
Reexamination Certificate
active
07022730
ABSTRACT:
This invention provides compounds which are useful as inhibitors of protein tyrosine phosphatases (PTPases). As inhibitors of PTPases the compounds of the invention are useful for the management, treatment, control and adjunct treatment of diseases in mammals mediated by PTPase activity. Such diseases include type I diabetes, type II diabetes, immune dysfunction, AIDS, autoimmunity, glucose intolerance, obesity, cancer, psoriasis, allergic diseases, infectious diseases, inflammatory diseases, diseases involving the modulated synthesis of growth hormone or the modulated synthesis of growth factors or cytokines which affect the production of growth hormone, or Alzheimer's disease.
REFERENCES:
patent: 3527517 (1970-09-01), Hackmann
patent: 3995088 (1976-11-01), Garner et al.
patent: 4072690 (1978-02-01), Garner et al.
patent: 4403791 (1983-09-01), Schmidt et al.
patent: 0 887 348 (1998-12-01), None
patent: WO 99/61435 (1999-12-01), None
patent: WO 01/16097 (2001-03-01), None
patent: WO 01/81307 (2001-11-01), None
Gray et al., CA 51:16466b, 1957.
D'Auria, Tetrahedron (1991), 47(44), pp. 9225-9230.
Dittmann et al., CA 103:22412, 1985.
Bergman et al., CA 90:204315, 1979.
Kramer et al., CA 86:199415, 1977.
Novak et al., Journal of Organic Chemistry (1976), 41(5), pp. 870-875.
Golub et al., Science, vol. 286, Oct. 15, 1999, pp. 531-537.
Iversen, L.F., et al., Steric Hindrance as a Basis for Structure-Based Design of Selective Inhibitors of Protein-Tyrosine Phosphatases, Biochemistry, 2001, 40, No. 49, 14812-14820.
Bleasdale, J.E., et al., Small Molecule Peptidomimectics Containing a Novel Phosphotyrosine Bioisostere Inhibit Protein Tyrosine Phosphatase 1B and Augment Insulin Action, Biochemistry, 2001, 40, 5642-5654.
Shim, Y.S., et al., Formylchromone Derivatives as a Novel Class of Protein Tyrosine Phosphatase 1B Inhibitors, Bioorganic & Medicinal Chemistry Letters, 13, (2003) 2561-2563.
Cheon, H.G., et al., Discovery of a Novel Protein Tyrosine Phosphatase-1N Inhibitor, KR61639: Potential Development as an Antihyperglycemic Agent, European Journal of Pharmacology, 485 (2004) 333-339.
Urbanek, R.A., et al., Potent Reversible Inhibitors of Protein Tyrosine Phosphatase CD45, J. Med. Chem., 2001, 44, 1777-1793.
Umezawa, K., et al., Molecular Design and Biological Activities of Protein-Tyrosine Phosphatase Inhibitors, Pharmacology & Therapeutics, 99, (2003), 15-24.
Sarmiento, M., et al., Structure-Based Discovery of Small Molecule Inhibitors Targeted to Protein Tyrosine Phosphatase 1B, J. Med. Chem., 2000, 43, 146-155.
Mjalli Adnan M. M.
Shahbaz Kathy G. J.
Kilpatrick & Stockton
Stockton Laura L.
TransTech Pharma, Inc.
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