Bis-esters of methanediol with acetonides of ampicillin or amoxi

Details Bis-esters of methanediol with acetonides of ampicillin or amoxi Bis-esters of methanediol with acetonides of ampicillin or amoxi

1981-03-23

1982-03-23

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424271, C07D49980

Patent

active

043211968

ABSTRACT:
Bis-esters of methanediol wherein one hydroxy group of the methanediol is esterified with the carboxy group of hetacillin (or of the p-hydroxy analog of hetacillin) and the other hydroxy group of the methanediol is esterified with penicillanic acid 1,1-dioxide. These orally effective compounds have a particularly broad spectrum of antibacterial activity in mammals, and have an unusually long serum half-life.

REFERENCES:
patent: 3198804 (1965-08-01), Johnson et al.
patent: 3954735 (1976-05-01), von Daehne
patent: 4185015 (1980-01-01), Sleezer et al.
patent: 4244951 (1981-01-01), Bigham
Handcastle et al., J. Org. Chem. 31, pp. 897-899 (1966).
Long et al., J. Chem. Soc. (C), pp. 1920-1922 (1971).

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