Bis-dioxopiperazine derivatives, antitumor agents comprising the

Details Bis-dioxopiperazine derivatives, antitumor agents comprising the Bis-dioxopiperazine derivatives, antitumor agents comprising the

1984-04-04

1988-04-12

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544121, 544 60, 544 8, 544120, 544372, 544385, A61K 31435, A61K 31535, A61K 3154, C07D41314

Patent

active

047374977

ABSTRACT:
Disclosed are novel bis-dioxopiperazine derivatives, process for their preparation, antitumor agents comprising them and compositions containing them.
The bis-dioxopiperazine derivatives are represented by the following general formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; R.sub.2 represents a hydrogen atom or a group of ##STR2## R.sub.3 and R.sub.4, which are respectively independent and are the same or different, represent respectively a lower alkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms or a heterocyclic radical selected from the group consisting of substituted or unsubstituted piperidino, substituted or unsubstituted piperazino, substituted or unsubstituted morpholino and substituted or unsubstituted thiomorpholino, or R.sub.3 and R.sub.4 are bonded together to form a group of ##STR3## which represents a cyclic amino group selected from the group consisting of substituted or unsubstituted pyrrolidino, substituted or unsubstituted piperidino, substituted or unsubstituted piperazino, substituted or unsubstituted morpholino, substituted or unsubstituted thiomorpholino and substituted or unsubstituted thiadiazino; and the substituents of the heterocyclic radical and the cyclic amino group are selected from the group consisting of a lower alkyl group having 1 to 4 carbon atoms, oxo and phenyl, said cyclic amino group being not morpholino when R.sub.1 is a hydrogen atom and R.sub.2 is the group of ##STR4##

REFERENCES:
Herman et al; CA 98:118919h (4/11/83) Biological Prop. of ICRF-159 and Related Compounds.
Zhang et al: CA 94:132202t (1980) Pharmacological Studies in Bimolane--A New Antineoplastic Agent.
Saikawa et al, CA 92:41991s-2,3-Dioxopiperazinl Derivatives, (1980).
Saikawa et al., CA 92:41992t, 1,4 Distributed 2,3-Dioxopiperizines (1980).

Affiliated with

Also associated with

Rating

Bis-dioxopiperazine derivatives, antitumor agents comprising the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bis-dioxopiperazine derivatives, antitumor agents comprising the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bis-dioxopiperazine derivatives, antitumor agents comprising the will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1429529