Bis diketopiperazines

Details Bis diketopiperazines Bis diketopiperazines

1974-02-21

1976-03-02

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268BF, 260561R, 260583R, 424250, C07D29510

Patent

active

039417905

ABSTRACT:
A pharmaceutical composition useful for aiding regression and palliation of cancer in mammals comprises a therapeutically effective amount of a compound of formula ##EQU1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen and methyl or together represent an ethylene bridging group, with the proviso that when both of the groups R.sub.1 and R.sub.2 are methyl they are disposed in the meso configuration, or a non-toxic salt thereof with a physiologically acceptable inorganic or organic acid, in combination with a physiologically acceptable diluent or carrier.

REFERENCES:
patent: 2628963 (1953-02-01), Laucius et al.
patent: 3196153 (1965-07-01), Dazzi
K. Hellmann et al., Nature, 1969, 224, 273.
Hellmann et al., Brit. Med. Jour., 1969, i, 822.
Creighton et al., Nature, 1969, 222, 384.
Badinand, "Bull, Soc. Chim. France," 1960, pp. 382-383.
Morrison et al., "Organic Chemistry" 1966, pp. 76-84.

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