Bis-carbazole DNA intercalating agents for antitumor therapy

Details Bis-carbazole DNA intercalating agents for antitumor therapy Bis-carbazole DNA intercalating agents for antitumor therapy

2011-04-05

2011-04-05

Nolan, Jason M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S411000, C546S070000, C548S448000, C548S440000, C548S441000, C548S444000

Reexamination Certificate

active

07919500

ABSTRACT:
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, wherein the rings are linked in a 1,4 or 1,3 manner. Methods of inhibiting cancer cells and treating subjects having cancer with these agents are also provided.

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Jaycox et al., “Potential DNA bis-Intercalating agents:synthesis and antitumor activity of novel, conformationally restricted bis(9-aminoacridines)”, J. Heterocyclic Chem. 1987 24:1405-1408.

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