Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1973-02-02
1977-12-20
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
260239B, 260268TR, 26029362, 2603265C, 2605705P, 42424857, C07D29510
Patent
active
040643476
ABSTRACT:
The novel bis-basic ketones of fluorene and fluorenone of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##STR1## wherein Z is oxygen or H.sub.2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is
A. the group ##STR2## wherein R.sup.1 and R.sup.2 are individually hydrogen, (lower)alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or
B. the group ##STR3## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R.sup.3 is hydrogen, (lower)alkyl of 1 to about 4 carbon atoms, phenyl, or benzyl and can be linked to any one of the carbon atoms of the heterocyclic group; or
C. the group ##STR4## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or (lower)alkyl of from 1 to about 4 carbon atoms; or
D. the group ##STR5## WHEREIN P IS A WHOLE INTEGER FROM 2 TO 3, AND M IS A WHOLE INTEGER FROM 1 TO 2; OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT OF SAID BASE.
These new compounds may be prepared by several different methods which are described.
REFERENCES:
patent: 2783216 (1957-02-01), Martin
patent: 2840558 (1958-06-01), Martin
patent: 3083201 (1963-03-01), Anderson
patent: 3231629 (1966-01-01), McCall et al.
patent: 3251733 (1966-05-01), Bindler et al.
Albrecht William L.
Fleming Robert W.
Horgan Stephen W.
Sill Arthur D.
Daus Donald G.
Rauchfuss, Jr. George W.
Retter Eugene O.
Richardson-Merrell Inc.
Tovar Jose
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