Bis-arylsulfonylaminobenzamide derivatives and the use thereof a

Details Bis-arylsulfonylaminobenzamide derivatives and the use thereof a Bis-arylsulfonylaminobenzamide derivatives and the use thereof a

1995-06-06

1997-03-18

Dees, Jos e G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514255, 514604, 514821, 514822, 514836, 514886, 544358, 544398, 544399, 544400, 564 80, 564 82, A61K 3118, C07C31116

Patent

active

056123787

ABSTRACT:
The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds of structure: ##STR1## wherein each R.sup.1 is independently one of alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl;
each R.sup.2 and R.sup.3 is independently one of hydrogen, alkyl, aryl or arylalkyl;
Y is a bond, or is one of --(CH.sub.2).sub.p --, cycloalkyl, aryl or C.sub.2-10 heterocycle; and
m, n and p are each independently 1 to 10.

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