Bis-anthracycline nucleic acid function inhibitors and improved

Details Bis-anthracycline nucleic acid function inhibitors and improved Bis-anthracycline nucleic acid function inhibitors and improved

1979-02-23

1981-04-21

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1708, A61K 3170

Patent

active

042634288

ABSTRACT:
A new group of compounds having an enhanced ability to inhibit nucleic acid functions have been prepared. These drugs are bis-anthracyclines wherein two anthracycline molecules are linked through their C-13 carbon atoms by amino and/or hydroxy-dicarboxylic acids and their derivatives to form the bis-compounds. Such bis-anthracyclines may be even more effectively delivered to selected sites in a mammalian organism by incorporating the same within uniformly sized liposomes.

REFERENCES:
patent: 4112217 (1978-09-01), Henry et al.

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