Bis- and tetrakis-phosphonates useful for treating calcium relat

Details Bis- and tetrakis-phosphonates useful for treating calcium relat Bis- and tetrakis-phosphonates useful for treating calcium relat

1992-05-13

1994-05-17

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

549 6, 549218, 558155, 558158, 558162, 562 14, 562 20, C07F 940, C07F 938, C07F 9655, C07F 9655.3

Patent

active

053129547

ABSTRACT:
Novel bisphosphonates comprise compounds of the formula (I) ##STR1## wherein m and l are independently 1 or 2; R.sub.1 represents hydrogen, a lower alkyl group, or an alkali metal cation; R.sub.2 represents hydrogen, a lower alkyl group or an alkali metal cation; Y represents .dbd.0 or .dbd.N--OH, or --OH and X represents --(CH.sub.2).sub.n --, a branched alkylene group, or a branched or straight alkenylene or alkynylene chain optionally substituted by one or more oxygen or nitrogen atoms, wherein n is an integer from 3 to 24. Further definitions of X are included in the description.

REFERENCES:
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patent: 4060546 (1977-11-01), Blaser et al.
Rafik Karaman et al, Acylphosphonic Acids and Methyl Hydrogen Acylphosphonates: Physical and Chemical Properties and Theoretical Calculations, J. Chem. Soc. 1989.
Kanaan et al, Phosphorus and Sulfur, 1988, vol. 37, pp. 217-229.
Hilderbrand, CRC, "The Role of Phosphonates in Living Systems", pp. 55-96, 161-188 1980.
The Merck Index; Eleventh Edition; Merck: Rahway, N.J., 1989; No. 1512.
Gallez, B. et al. Chem. Abstr. 110(2), 13646c, Appl. Radiat. Isot. 1988, 39(9), 1011-14.
Chem. Abstr.1988, 109(7), 54960a; BE 1000075A1 Feb. 2, 1988.

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