Bis-amino acid hydroxyethylamino sulfonamide retroviral protease

Details Bis-amino acid hydroxyethylamino sulfonamide retroviral protease Bis-amino acid hydroxyethylamino sulfonamide retroviral protease

1995-06-07

2000-11-21

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564 90, 514604, C07C31116, A61K 3118

Patent

active

061505560

ABSTRACT:
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

REFERENCES:
patent: H725 (1990-01-01), Gordon
patent: 4450164 (1984-05-01), Gordon et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4595407 (1986-06-01), Carter
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4634465 (1987-01-01), Ehrenfreund et al.
patent: 4668769 (1987-05-01), Hoover
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4880938 (1989-11-01), Freidinger
patent: 4963530 (1990-10-01), Hemmi et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
patent: 5585397 (1996-12-01), Tung et al.
patent: 5744481 (1998-04-01), Vazquez et al.
International Search Report of PCT/US96/02685 dated Jul. 25, 1996.
Roberts et al, Science, 248, 358 (1990).
Erickson et al, Science, 249, 527 (1990).
Pearl et al, Nature, 328 (1987).
Martin, Drugs of the Future, 1991, 16(3), 210-212.
Meek et al, Nature, 343:90-92, (1990).
McQuade et al, Science, 274, 454 (1990).
Rich et al, Pept. Struct. Funct. Proc. Am. Pept. Sym. 8th ed. pp. 511-520 (1983).
Rosenberg et al, J. Med. Chem., 30, 1224-1228 (1987).
Fittkau, J. Prakt. Chem., 315, 1037 (1973).
Hirsh et al, N. Eng. J. Med., 328, 1686 (1993).
E.E. Gilbert, "Recent Developments in Preparative Sulfonation and Sulfation", Synthesis, 3 (1969).
Silcox et al, J. Heterocycl. Chem., 4, 166-67 (1967.
Cabiddu et al, Synthesis, 797-798 (1976).
Ncube et al, Tet. Lett, 26, 2345-2348 (1978).
Ncube et al, Tet. Lett., 3, 255-256 (1977).
Cole et al, Aust. J. Chem., 33, 675-80 (1980).

Affiliated with

Also associated with

Rating

Bis-amino acid hydroxyethylamino sulfonamide retroviral protease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bis-amino acid hydroxyethylamino sulfonamide retroviral protease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bis-amino acid hydroxyethylamino sulfonamide retroviral protease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1258944