Bis-amidine indene ketones, compositions containing same and met

Details Bis-amidine indene ketones, compositions containing same and met Bis-amidine indene ketones, compositions containing same and met

1981-06-05

1983-02-01

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424326, 562440, 564243, A61K 31155, A61K 31195, C07C12300

Patent

active

043715435

ABSTRACT:
Bis-amidine indene ketones are provided having the structure ##STR1## wherein R is hydrogen, lower alkyl or aryl; and R.sup.1 is hydrogen, lower alkyl, halogen, carboxy, trifluoromethyl, lower alkoxy, hydroxy or acyl, and acid-addition salts thereof. In addition, pharmaceutical compositions containing the above compounds and a method of using same to treat inflammatory conditions in mammalian species are also provided.

REFERENCES:
patent: 2395471 (1946-02-01), Ewins
patent: 4078086 (1978-03-01), Winkelmann et al.
patent: 4086244 (1978-04-01), Sprague
patent: 4108894 (1978-08-01), Sprague
"Synthese von .alpha.,.alpha.-Bis-[amidinobenzyliden]-und.alpha.,.alpha.'-Bis-[amidinobe nzyl]-cycloalkanonen", Wagner et al., Pharmazie 32, pp. 141-145 (1977).

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