Bis-acyloxymethyl derivatives

Details Bis-acyloxymethyl derivatives Bis-acyloxymethyl derivatives

1991-07-15

1996-12-10

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514297, 514307, 514314, 546104, 546143, 546151, 546156, 546159, 5462791, 5462764, 5462767, 548518, 548561, C07D21908, C07D21710, C07D21510, A61K 31435

Patent

active

055831486

ABSTRACT:
This invention relates to new pyridyl, quinoline and acridine bis-acyloxymethyl compounds; to compositions comprising these compounds; and to processes for their utility as fungicides, bactericides and as inhibitors of the growth of cancer in warm-blooded animals. In accordance with this invention, new bis-acyloxymethyl derivatives are provided of the formula: ##STR1## wherein B is selected from substituted and unsubstituted alkyl, cycloalkyl, aryl, alkenyl, cycloalkenyl and alkynyl; A is selected from hydrogen and B; or, A and B together comprise a pyrrolizine; L is selected from ##STR2## wherein Y is selected from hydrogen or ##STR3## each R and Z is independently selected from hydrogen or substituted and unsubstituted alkyl, cycloalkyl, aryl, alkenyl, cycloalkenyl, alkynyl, amine group, each Z' is independently selected from hydrogen and substituted or unsubstituted alkyl; M is Z or is selected from halogen, nitro, hydroxyl, nitrile and substituted or unsubstituted, carboxylic acid group, carboxylic acid ester group, carboxylic acid amide group, sulfonic acid group and sulfonic acid amide group; ether group, thioether group, acylated hydroxyl, sulfonylamide, sulfonylurea, sulfoxide group, sulfone group and mixtures thereof; each n is the same and is 0 or 1; q is from 0-4; and, X is the anion of an acid.

REFERENCES:
patent: 4529728 (1985-07-01), Fabre
patent: 4539400 (1985-09-01), Fabre
patent: 4684658 (1987-08-01), Fabre
Moossa et al "Oncology" William & Wilkins, p. 199 (1986).
DeVita "Cancer Principle and Practice of Oncology" Lippincott, p. 144-145 (1985).
Pazden et al "Correlation of Murine Anti tumor Models in Predicting Clinical Drug Activity in Nonsuall Cell by Cancer" Proc. Am. Soc. Clin. Oncology 3 p. 219 (1984).
Heim et al "L-Aspanaginase in the Treatment of Solid Tumor" Chem. Pharm. Abst. from Dtsch. Med. Wochschr. 95:989-93 (May 1, 1970).
Boyd et al "Basic Medical Microbiology" Brown & Co. pp. 117-139 (1977) Martin et al "Role of Marine Tumor Model" Cancer Re. 462189-92 (1986).

Affiliated with

Also associated with

Rating

Bis-acyloxymethyl derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bis-acyloxymethyl derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bis-acyloxymethyl derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-424505