Bis-2-furanidyl ether and method of preparation

Details Bis-2-furanidyl ether and method of preparation Bis-2-furanidyl ether and method of preparation

1979-04-30

1980-07-15

Raymond, Richard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D30720

Patent

active

042128145

ABSTRACT:
The present invention relates to a new process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro-uracil, also called Ftorafur, which is a very important anti-cancer compound. Said process comprises reacting 2,3-dihydrofuran with water in the presence of a catalytic amount of an acidic catalyst at a pH below 2.5, removing excess of unreacted starting materials and reacting the mixture obtained with silylated-5-fluoro-uracil is in the presence of a Friedel Crafts type catalyst uracil in an inert organic solvent. The new process has many advantages in comparison with those used so far.

REFERENCES:
Bagnall et al, JACS, vol. 73 (1951) pp. 4794-4798.
Dunlop et al, The Furans, Rheinhold Publishing Corp., New York (1953), p. 686.
Huben-Weyl, Methoden der Organischen Chemie vol. 6/3 Georg Thieme Verlag, Stuttgart, Germany (1965) pp. 723 and 699.

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