Bis-(2-aryl) hydrazones

Details Bis-(2-aryl) hydrazones Bis-(2-aryl) hydrazones

1995-06-07

1997-08-26

Nazario-Gonzalez, Porfirio

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514351, 514353, 514565, 514639, 546300, 546306, 562439, 564251, A61K 3166, C07D21172, C07C24100

Patent

active

056611390

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a bis-(2-aryl)hydrazone capable of inhibiting the formation of advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

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