Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1983-04-12
1985-10-01
Daus, Donald G.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07D20306, A61K 31395
Patent
active
045445010
ABSTRACT:
Novel bis(2,2-dimethyl-1-aziridinyl)phosphinic amide antineoplastic agents are disclosed of the formula: ##STR1## wherein R and R' are each, independently, hydrogen, alkyl, substituted alkyl, phenyl and substituted phenyl and, Z is oxygen or sulfur.
REFERENCES:
patent: 3201313 (1965-08-01), Bardos et al.
Lalka et al., J. Pharm. Science, 62(8) (1973), pp. 1294-1298.
Chem. Abstracts 67:21748y (1967).
Chernov et al., Chem. Abstracts, vol. 62, (1965), Abst:15243d.
Orrie et al., Chem. Abstracts, vol. 59, (1963), Abst:6337a.
Wodinsky et al., Combined Therapy with an Aziridine Derivative NSC 200724 (Ab182) and Radiation on an Experimental Leukemia, Int. J. Radiation Oncology Biol. Phys., vol. 5, pp. 1677-1680, 1979.
Hsiao et al., Synthesis of New Bis(1-Aziridinyl)Phosphinate Alkylating Agents Containing O-Phenyl N-Phenylcarbamate Side Chains, Jour. of Med. Chem., vol. 16, p. 391, 1973.
Wampler et al., Absence of Cross-Resistance to Alkylating Agents in Cyclophosphamide-Resistant L1210 Leukemia, Europ. J. Cancer, vol. 14, pp. 977-982, 1978.
Bardos et al., Synthesis of Potential Dual Antagonists III, Jour. of Pharmaceutical Sciences, vol. 54, No. 2, Feb., 1965.
Chmielewicz et al., Synthesis and Chemotherapeutic Effects of Ethyl Bis-(2,2-Dimethyl)-Ethylenamido Phosphate. A Preliminary Report, Jour. of Pharmaceutical Sciences, vol. 56, No. 9, Sep. 1967.
Bardos et al., Structure-Activity Relationships of Alkylating Agents in Cancer Chemotherapy, Annals of The New York Academy of Sciences, vol. 163, Article 2, pp. 1006-1025, Oct. 3, 1969.
Chmielewicz et al., Alterations of Some Macromolecular and Biochemical Properties of Calf Thymus DNA Caused by "Dual Antagonists" and Nitrogen Mustard, Cancer Research, 27, pp. 1248-1257, Jul. 1967.
Munson et al., Preparation and Antitumor Activity of Tris(2,2-Dimethyl-1-Aziridinyl)Phosphine Oxide (TEPA-132), Cancer Chemotherapy Reports, vol. 51, No. 5, pp. 253-259, Sep. 1967.
Bardos et al., Effects of Ring-C-Methyl Substituents on the Chemical and Biological Activities of Ethylenimine Type Alkylating Agents, Int. Congress of Chemotherapy, Jun. 1967.
Bardos, Antimetabolites: Molecular Design and Mode of Action, Topics in Current Chemistry, vol. 52, pp. 90 and 91 only, 1974.
Lalka et al., Cyclophosphamide, 2,2-Dimethyl-Aziridines and Other Alkylating Agents as Inhibitors of Serum Cholinesterase, Biochemical Pharmacology, vol. 24, pp. 455-462, 1975.
Lalka et al., Reactions of 2,2-Dimethyl-Aziridine-Type Alkylating Agents in Biological Systems II: Comparative Pharmacokinetics in Dogs, Jour. of Pharmaceutical Sciences, vol. 64, No. 2, Feb., 1975.
Bardos et al., Chemical Mechanism of the Radiation Potentiating Effects of 2,2-Dimethylaziridine-Type Antitumor Agents, Int. J. Radiation Oncology Biol. Phys., vol. 5, pp. 1653-1656, 1979.
Wampler et al., Radiation Potentiating Effect of Ethyl Bis(2,2-Dimethyl-1-Aziridinyl)Phosphinate (AB-163), Int. J. Radiation Oncology Biol. Phys., vol. 5, pp. 1681-1683, 1979.
Hsiao et al., Synthesis of 5'-Thymidinyl Bis(1-Aziridinyl)Phosphinates as Antineoplastic Agents, Jour. of Med. Chemistry, vol. 24, pp. 887-889, 1981.
Zhdanov et al., Biologically Active Stable Radicals; XV.sup.1. Spin-Labeled Alkyl Carbamate-N-Phosphonic Acid Aziridides, "Synthesis", pp. 269-271, 1979.
Konieczny et al., Methods for the Preparation of Spin-Labeled Phosphorus Compounds and Applications of Some of Them to Phosphorylative Spin-Labeling, "Synthesis", Sep. 1981.
Kimler et al., Development and Testing of New Hypoxic Cell Radiosensitizers, Radiology, vol. 33, pp. 515-517, 1979.
Bardos et al., Synthesis of Potential Dual Antagonists IV, Jour. of Pharmaceutical Sciences, vol. 54, No. 3, Mar., 1965.
Hsiao et al., Synthesis of Bis(Aziridinyl)Phosphinyl-N-Hydroxy-Urethane Derivatives as Antineoplastic Agents, Jour. of Medical Chemistry, vol. 18, p. 195, 1975.
Bardos et al., Combination of Chemotherapy with Dual Antagonists and Radiotherapy in the Treatment of Neoplastic Disease, Journal of Surgical Oncology 3(4); pp. 431-441, 1971.
Bardos Thomas J.
MacDiarmid Joan E.
Perlman Michael E.
Crossetta William J.
Daus Donald G.
Dunn Michael L.
Teoli, Jr. William A.
The Research Foundation of State University of New York
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