Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the p

Details Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the p Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the p

1994-09-12

1996-05-14

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544144, 544373, 546201, C07D40114, C07D40314, C07D41314

Patent

active

055169155

ABSTRACT:
The present invention provides bis-(1H-indol-3-yl)maleinimide derivatives and the pharmacologically acceptable salts thereof, processes for the preparation of these compounds, and pharmaceutical compositions containing them for the treatment of heart and blood vessel diseases, such as thromboses, arteriosclerosis, hypertension, of inflammatory processes, allergies, cancer, and certain degenerative damages of the central nervous system, as well as of diseases of the immune system and viral diseases.

REFERENCES:
patent: 4912107 (1990-03-01), Kleinschroth et al.
Tetrahedron Letters, 28(38):4441-4444 (1987), J. Bergman et al., "Coupling of Indoleacetic Acid Trianion . . . ".
Febs Lett., 259(1):61-63 (1989), P. D. Davis et al., "Potent Selective Inhibitors of Protein Kinase-C".

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