Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the p

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514422, 5142352, 514340, 514 43, 548455, 548430, 546198, 544142, 544143, 536 286, C07D40114, C07D40314, C07D41314, A61K 3140, A61K 31445, A61K 31535

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active

053807464

ABSTRACT:
The present invention provides bis-(1H-indol-3-yl)maleinimide derivatives and the pharmacologically acceptable salts thereof, processes for the preparation of these compounds, and pharmaceutical compositions containing them for the treatment of heart and blood vessel diseases, such as thromboses, arteriosclerosis, hypertension, of inflammatory processes, allergies, cancer, and certain degenerative damages of the central nervous system, as well as of diseases of the immune system and viral diseases.

REFERENCES:
patent: 4912107 (1990-03-01), Kleinschroth et al.
Tetrahedron Letters, 28(38):4441-4444 (1987), J. Bergman et al., "Coupling of Indoleacetic Acid Trianion . . .".
Febs Lett., 259(1): 61-63 (1989), P. D. Davis et al., "Potent Selective Inhibitors of Protein Kinase-C".

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