Birth control vaccine

Drug – bio-affecting and body treating compositions – Lymphokine

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424 95, 424105, 514 21, 530399, 530402, 530403, 530405, A61K 3724

Patent

active

047803126

ABSTRACT:
A polyvalent vaccine for control of fertility is disclosed, the vaccine having a multiplicity of determinant antigens in the reproductive system of mammals, the antigens being linked to at least one carrier. The precise manner of linkage can differ, and preferably more than one carrier is present thereby increasing antibody response particularly in those subjects who are poor responders when a single carrier only is used. The new vaccine thus has a multi-valent capability against the reproductive system and also preferably the capability of producing immunoprophylactic benefit against more than one health hazard.

REFERENCES:
patent: 4161519 (1979-07-01), Talwar
Nash et al., J Reproductive Immunol 7, 1985, pp. 151-162.
"Immunofluorescense and Electron Microscopie Studies on Kidney, Chorid Plexus and Pituitary in Rhesus Monkeys Immunized with the Anti-hCG Vaccine Pr-B-HCG-TT", Gupta et al; Contraception (1978).
"Observations on the Antigenicity and Clinical Effects of a Candidate Antipregnancy Vaccine: B-Subunit of Human Chorionic Gonadotrophin Linked to Tetanus Toxoid", Nash et al; The American Fertility Society (1979).
"Effects of Pregnancy in Mice of Passive Immunization Against Ovine LH and Human Chorionic Gonadotrophin", Tandon et al; Journals of Reproduction & Fertility (1984).
"Important Role of the Carrier in the Induction of Antibody Response Without Freund's Complete Adjuvant Against a `Self` Peptide Luteinizing Hormone-Releasing Hormone (LHRH)", N. Shastri et al; American Journal of Reproductive Immunology, (1981).
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"Immunological Methods to Prevent Pregnancy", S. J. Segal; Contraception (1976).
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"Discriminatory Effect of Anti-Pr-B-hCG-TT Antibodies on Neutralization of the Biological Activity of Placental and Pituitary Gonadotrpins", C. Das et al; Contraception, (1978).
"Progesterone Levels in Monkeys Immunized with Pr-B-hCG-TT After Injection of hLH and hCG During Luteal Phase", S. Ramakrishnan; Contraception (1978).
"Differences Between the Discriminatory Activity of Antisera Raised Against the Total Gonadotropins and the Pr-B-hCG-TT for Neutralization of hCG and LH Action", P. Mohini et al; Contraception (1978).
"Nature of Immune Complexes Formed in Rhesus Monkeys Immunized with Pr-B-hCG-TT on Challenge with hCG", S. Ramakrishnan; Contraception (1978).
"The Effectiveness in Rhesus Monkeys of an Antifertility Vaccine Based on Neutralization of Chorionic Gonadotropin", K. Sundaram et al; Contraception (1976).
"Human Chorionic Gonadotropin Stimulates Luteal Function in Rhesus Monkeys Immunized Against the B-Subunit of Ovine Luteinizing Hormone", R. Thau et al; Endochronology (1983).
"Characterization of Anti oLHB-Antibodies Acting as Contraceptives in Rhesus Monkeys. I. In Vitro Binding Properties", Y. Yamamoto et al; Journal of Reproductive Immunology (1982).
"Characterizations of Anti-oLHB Antibodies Acting as Contraceptives in Rhesus Monkeys, II, In Vivo Neutralizing Ability for Gonadotropic Hormones", Y. Yamamoto et al; Journal of Reproductive Immunology (1983).
"Effects of Immunization with the B-Subunit of Ovine Luteinizing Hormone on Corpus Luteum Function in the Rhesus Monkey", R. Thau et al; Fertility & Sterility (1979).
"Effects of Long-Term Immunization Against the B-Subunit of Ovine LH on Circulating Immune Complex Formation and on Arterial Changes in Rhesus Monkeys", R. Thau et al.
Int. J. Peptide Protein Res. 27, 1986, 604-612.
Immunological Approaches to Contraception and Promotion of Fertility (1988), 17-24.
Immunological Approaches to Contraception and Promotion of Fertility (1986), 37-41.
Reproductive Immunology (1986), 178-183.
Fertility and Sterility 46 (1) (1986), 120-126.
Fertility Regulation Today and Tomorrow (1987), 43-54.
Recent Advances in Clinical Immunology 4 (1987), 183-200.

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